Open AccessEnhancement of Aqueous Solubility and Dissolution Profile of Atorvastatin Calcium: In vitro Evaluation of Solid Dispersion
Author(s) -
Pawar AR,
AUTHOR_ID,
Mehetre JS,
AUTHOR_ID
Publication year - 2021
Publication title -
journal of pharmaceutical research and reports
Language(s) - English
Resource type - Journals
ISSN - 2754-5008
DOI - 10.47363/jprsr/2021(2)121
Subject(s) - dissolution , solubility , atorvastatin , calcium , chemistry , dispersion (optics) , aqueous solution , permeability (electromagnetism) , chemical engineering , materials science , chromatography , pharmacology , organic chemistry , biochemistry , medicine , engineering , physics , membrane , optics
Purpose: The objective of the present study was to formulate solid dispersions (SD) of Atorvastatin calcium to improve the aqueous solubility and dissolution rate to facilitate faster onset of action. Atorvastatin calcium is a lipid lowering agent belonging to BCS-II having low solubility and high permeability.