A Review on the Neuroendocrine Regulation of the Endothelial Cells

Today, it is known that inflammation represents the common mechanism of human systemic diseases, including cancer and autoimmunity. Obviously, the endothelial system is involved in all inflammatory processes. Then, the control of the endothelial functions could constitute a new medical strategy to treat several pathological conditions, including ischemic and thrombotic events. Moreover, in addition to the action of angiogenic and anti-angiogenic factors, the endothelial system has been proven to be physiologically under a double control, represent by the cytokine network and the neuroendocrine system. Most cytokines have appeared to exert angiogenic and inflammatory effects, which are balanced by an anti-angiogenic and an anti-inflammatory action exerted by the pineal hormone melatonin (MLT), cannabinoid agents, and the product of ACE2, the angiotensin 1-7 (Ang 1-7). Then, a neuroendocrine approach with MLT, cannabinoids and Ang 1-7 could constitute a new way in the treatment of endothelial alterations and angiogenesis.