Open AccessEco- Friendly Ultraviolet Spectrophotometric Determination of Allopurinol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing
Author(s) -
Nief Rahman Ahmed
Publication year - 2021
Publication title -
journal of infectious diseases and case reports
Language(s) - English
Resource type - Journals
ISSN - 2634-8861
DOI - 10.47363/jidscr/2021(2)136
Subject(s) - allopurinol , chromatography , absorbance , distilled water , wastewater , chemistry , dosage form , environmental science , environmental engineering , medicine , pathology
A simple, economical and sensitive UV spectrophotometric method has been developed for the determination of allopurinol in environmental wastewater samples and, pharmaceutical preparations which shows maximum absorbance at 250 nm in distilled water. Beer’s law was obeyed in the range of 1 - 20 μg/ ml, with molar absorptive of 0.628 x104 l/mol.cm L.mol-1.cm-1 .The method was successfully applied to the determination of allopurinol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of allopurinol in true samples.