Open AccessIsopropyl Nitrite Induced Hemoglobin Oxidation in Diabetics Blood
Author(s) -
John Philip Tarburton
Publication year - 2020
Language(s) - English
DOI - 10.47363/jdrr/2020(2)104
Subject(s) - nitrite , methemoglobin , hemoglobin , chemistry , isopropyl , medicine , biochemistry , endocrinology , medicinal chemistry , organic chemistry , nitrate
The effect of isopropyl nitrite on human Type 2 Diabetes blood was undertaken using non diabetics blood as the control group. The differences in patient characteristics such as the mean ages and weights of the two groups were not statistically significant (P>0.05), and the ratios of non-smokers to smokers were similar meaning that the two groups were well matched. These studies revealed that diabetics erythrocytes with a mean HbA1C value ± SEM of 11.4 ± 0.27% were oxidized at a significantly greater rate than that of the control blood (P 0.05). These findings also imply that the increased susceptibility to isopropyl nitrite induced oxidation reaction in diabetics blood is a direct function of the amount of HbA1C present in the blood, i.e., a clear inverse relation appears to exist between the amount of HbA1C present and the oxidation time