Open AccessA Prospective, Interventional Study of Oral Tranexamic Acid With Antioxidants and Local Glycolic Acid for The Treatment of Resistant Melasma
Author(s) -
Deepak Parikh,
AUTHOR_ID,
Piyu Parth Naik,
AUTHOR_ID
Publication year - 2021
Language(s) - English
DOI - 10.47363/jdmrs/2021(2)132
Subject(s) - melasma , medicine , glycolic acid , tranexamic acid , hyperpigmentation , dermatology , prospective cohort study , randomized controlled trial , surgery , lactic acid , blood loss , biology , bacteria , genetics
Background: Melasma is a common acquired hyperpigmentation of sun-exposed areas. It is highly treatment resistant and with high chances of recurrence. Treatment of melasma using oral tranexamic acid (TA) with antioxidants and glycolic acid is a novel concept. Objective: Aim of the study was to assess efficacy and safety of novel combination therapy for the treatment of resistant melasma. Method: It was a prospective interventional trial conducted on a total of 10 patients with melasma, who did not respond to topical skin lightening therapy. The severity and extent of pigmentation was assessed by modified melasma area severity index (mMASI). Patients were then prescribed oral TA with high dose of vitamin C, Iron & folic acid along with local glycolic acid. The response to treatment was assessed by mMASI and clinical photographs at 8th week and after 3 months on completion. Result: Significant difference between mMASI was observed among the study population. 60% patients showed 100% improvement and 40% showed 75% improvement from the baseline mMASI at 8 weeks after commencing treatment and 100% patients showed 100% improvement on 3 months completion. Conclusion: Based on the study results, oral TA in combination with antioxidants and glycolic acid can be used as a potential new, effective, and safe treatment for resistant melasma