Open AccessSpinal Peri-Neural Cysts Signficant or Innocent?
Author(s) -
Marina-Portia Anthony,
Sydney Castlereagh Radiology,
Michael Houang,
George Weisz,
Australia Castlereagh Radiology Sydney
Publication year - 2020
Publication title -
journal of clinical case studies reviews and reports
Language(s) - English
Resource type - Journals
ISSN - 2634-680X
DOI - 10.47363/jccsr/2020(2)148
Subject(s) - medicine , malignancy , vasculitis , incidence (geometry) , cyclophosphamide , jaundice , gastroenterology , anti neutrophil cytoplasmic antibody , adverse effect , surgery , dermatology , chemotherapy , disease , physics , optics
Antineutrophil cytoplasmic antibody (ANCA) - associated vasculitis is a severe autoimmune disorder. Its prognosis has been markedly improved by the introduction of immunosuppressive treatments. Nevertheless, this has been associated with an increased incidence of malignancy. We report the case of a 60-year-old woman who presented C-ANCA vasculitis with renal failure and pulmonary involvement requiring immunosuppressive therapy. A complete remission was achieved. After a follow-up of 22 months, she presented asthenia with fever and jaundice. The diagnosis of locally advanced peri-hilar cholangiocarcinoma was made. The outcome was unfavorable and the patient died. The incidence of malignancies is increased in ANCA vasculitis. Biliary tumors are uncommon compared to other cancers. The risk is mainly related to exposure to cyclophosphamide.