Open AccessMicroscopic polyangiitis: Modern concepts and treatment options
Author(s) -
И. Т. Муркамилов,
К А Айтбаев,
В В Фомин,
Indira Kudaibergenova,
F. A. Yusupov,
Ж. А. Муркамилова,
Т. В. Бекетова
Publication year - 2021
Publication title -
naučno-praktičeskaâ revmatologiâ
Language(s) - English
Resource type - Journals
eISSN - 1995-4492
pISSN - 1995-4484
DOI - 10.47360/1995-4484-2021-608-614
Subject(s) - microscopic polyangiitis , rituximab , granulomatosis with polyangiitis , medicine , rapidly progressive glomerulonephritis , plasmapheresis , pathology , vasculitis , immunology , disease , antibody , lymphoma
The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.