Open AccessRecurrent Polychondritis as a Paraneoplastic Phenomenon in a Patient With Myelodysplastic Syndrome
Author(s) -
Nadia Riscanevo,
Diego Federico Baenas,
Janet Flores,
Francisco Caeiro,
Verónica Saurit,
Alejandro Alvarellos,
Juan Pablo Pirola,
Julieta Olmedo,
Gastón Caeiro
Publication year - 2020
Publication title -
revista argentina de reumatología
Language(s) - English
Resource type - Journals
eISSN - 2362-3675
pISSN - 0327-4411
DOI - 10.47196/rar.v31i2.414
Subject(s) - relapsing polychondritis , medicine , myelodysplastic syndromes , polyarthritis , dermatology , autoantibody , vasculitis , immunology , disease , pathology , arthritis , bone marrow , antibody
Myelodysplastic syndromes are a heterogeneous group of hematological diseases, characterized by ineffective hematopoiesis with risk of progression to acute myeloid leukemia. They can be associated to autoimmune manifestations in 10-30% of patients, appearing before, during or after the diagnosis of the hematological disorder. The prevalence of relapsing polychondritis as a paraneoplastic phenomenon is 0.7-5.4%, occurring simultaneously in the majority of cases. Other associated autoimmune processes include: systemic vasculitis, seronegative polyarthritis, neutrophilic dermatosis, immunomediated cytopenias, presence of autoantibodies and cryoglobulinemia. We report the case of a 60-year-old woman, with no previous medical history, who presented with recurrent polychondritis and systemic vasculitis associated with myelodysplasia.