Open AccessDiagnostic methods in the study of Autoimmune Inflammatory Myopathies
Author(s) -
Graciela Gómez,
María de los Ángeles Gargiulo,
Amelia Granel,
Ana Isabel Sánchez Marcos,
Roberto Gómez,
Andrea Braillard Poccard,
Carolina Costi,
Mercedes García,
María Nieves Lojo,
Verónica Wernicke,
Belen I Barrios,
Sílvia Papasidero,
Alejandro Benítez,
Malena Viola,
María Celina de la Vega,
Mariana M Aciar,
M. E. Crespo Espindola,
Dafne Capelusnik,
Emilce Schneerberger,
M. Cosatti,
Cecilia Pisoni,
Yessica Ponce Delgado,
Oscar Rillo,
Susana Pineda,
Damián Duartes Noé,
Mariano Rivero,
Paula Girard Bosch,
Rodrigo García Salinas,
Boris Kisluk,
Guillermo Berbotto,
Roberto Movia,
Susana Visentini,
Gladys Herrera,
María Alicia Lázaro
Publication year - 2020
Publication title -
revista argentina de reumatología
Language(s) - English
Resource type - Journals
eISSN - 2362-3675
pISSN - 0327-4411
DOI - 10.47196/rar.v31i1.420
Subject(s) - myositis , dermatomyositis , polymyositis , medicine , inclusion body myositis , muscle biopsy , interstitial lung disease , autoantibody , pathology , overlap syndrome , antibody , dermatology , gastroenterology , disease , immunology , biopsy , lung
The Idiopathic Inflammatory Myopathies (IIM) comprise a heterogeneous group of acquired muscle diseases classified as polymyositis (PM), dermatomyositis (DM), Inclusion Body Myositis(IBM), ImmunoMediated Necrotizing Myopathies, (IMNM), Overlap Myositis(OM), juvenile myositis, Antisynthethase Syndrome (ASS) and cancer related myositis(CAM). The presence of myositis specific antibodies in the serum and autoantibodies against target antigens and inflammatory infiltrates in muscle tissue suggests the autoimmune condition of the disease. The diagnosis of inflammatory myopathies is often a challenge and the disposal of diagnostic tools are not always available in daily practice. Information on the accessibility of these methods was obtained from the Argentine Register of Myopathies. The study of muscle enzymes, ANA, anti-Jo-1 antibodies and chest tomography were easy to get to most patients while muscle MRI, lung diffusion capacity for carbon monoxide (DLco%) and muscle biopsy were performed in less than 50% of cases. Other myositis specific antibodies, necessary for disease diagnosis and prognosis, were mostly done through a subsidy from the Argentine Rheumatology Society.