Open AccessAcute Portal Vein, Superior Mesenteric Vein and Splenic Vein Thrombosis Secondary to JAK2 V617 Mutation- A Case Report
Author(s) -
Rosly R Jacob,
Anilkumar Ashokan,
Harikrishnan Somasekran,
Abhishek Sasidharan,
Sachin Chandran,
Venkatesh Mony Chandry
Publication year - 2021
Publication title -
international journal of medical science and clinical research studies
Language(s) - English
Resource type - Journals
eISSN - 2767-8342
pISSN - 2767-8326
DOI - 10.47191/ijmscrs/v1-i9-07
Subject(s) - medicine , portal vein thrombosis , asymptomatic , thrombosis , myeloproliferative neoplasm , ascites , mesenteric vein , malignancy , portal hypertension , abdominal pain , splenic vein , gastroenterology , radiology , cirrhosis , superior mesenteric vein , mesenteric ischemia , inferior mesenteric vein , vein , ischemia , portal vein , myelofibrosis , bone marrow
Portal vein thrombosis (PVT) is a rare finding which usually occurs in association with local factors such as cirrhosis, malignancy, pancreatitis, intraabdominal infections or systemic hypercoagulable states. It may present acutely as abdominal pain, ascites, fever or exist in a chronic state which is generally asymptomatic and an incidental finding. With advancement in Imaging and laboratory studies, PVT cases are diagnosed more frequently along with its predisposing factors. The invention of JAK2 mutation and it’s addition to the WHO criteria for Myeloproliferative neoplasm (MPN) diagnosis, has increased the number of MPN cases which were previously labelled idiopathic. We present a case of 54 year old female diagnosed with unprovoked PVT with bowel ischemia and JAK 2 mutation positive, managed surgically and with long term anticoagulation.