Open AccessInfluence of Antidepressant Medication on Short Term Memory in Chronic Mild Stress Mouse Model of Depression
Author(s) -
Saeed Mustapha,
Majidat Oshafu,
Umar Muhammad Adam,
Yusuf Yusha’u,
Abubakar Daku
Publication year - 2021
Publication title -
nigerian journal of neuroscience
Language(s) - English
Resource type - Journals
ISSN - 1116-4182
DOI - 10.47081/njn2021.12.1/003
Subject(s) - paroxetine , antidepressant , depression (economics) , memory impairment , psychology , short term memory , chronic stress , medicine , cognition , psychiatry , working memory , hippocampus , economics , macroeconomics
Depression is among the most prevalent diseases worldwide. Researchers have identified a link between depression and different types of memory loss, including short term memory (STM). Also, the memory impairment in depression is a function of severity. This study was conducted to evaluate the effect of antidepressant medication on short term memory in chronic mild stress (CMS) mouse model of depression. A total of eighteen female mice were randomly divided into three groups of six mice each (n=6). Group I served as normal control, group II were exposed to CMS for 14 days, group III were exposed to CMS for 14 days, and thereafter treated with paroxetine at a dose of 20 mg/kg for 14 days. Short term memory was assessed using batteries of cognitive tests including the Y-maze and novel object recognition. Further antidepressant effect was measured using the tail suspension test (TST). The results showed that paroxetine at 20 mg/kg significantly improved the short term memory of the depressed female mice (p<0.05) in the Y-maze and novel object (recognition) tasks after CMS. Therefore, paroxetine might be used to enhance short term memory in depressed individuals, although clinical studies are required to confirm this finding.