Open AccessRole of Topical Heparin in Treatment of Burn at Tertiary Care Hospital in Western Rajasthan
Author(s) -
Dharmveer Jajra,
Sanjay Lodha,
Ashok Kumar,
Diwan Singh Jakhar,
Joginder Singh
Publication year - 2020
Publication title -
academia journal of surgery
Language(s) - English
Resource type - Journals
eISSN - 2663-8347
pISSN - 2663-8339
DOI - 10.47008/ajs/2020.3.1.24
Subject(s) - medicine , heparin , burn injury , anesthesia , surgery
Background: Heparin is a multifaceted compound with uses not only as an anticoagulant, but also as an anti-inflammatory, anti-allergenic, anti-histaminic, anti-serotonin, anti-proteolytic and neoangiogenic agent. The aim of the study was to study the effect of topical heparin in the management of burns in terms of morbidity, mortality & safety. Subjects and Methods: A hospital based RCT with total duration of 16 months from June, 2018 to September, 2019 with 100 patients (age between 15-45 years, burns from 20-60%, with less than 48 hours duration), randomly enrolled into 2 groups, after initial resuscitative measures, 50 cases receiving Topical Heparin treatment, 50 controls receiving conventional treatment (1% silver sulphadiazine) with i.v. antibiotics, after explaining the study objectives and taking informed written consent. Data analysis was performed using Epi Info software. Results: Patients treated with topical heparin experienced statistically significant (p<0.05) improved pain relief, rapid healing, lesser complications and reduced duration of hospital stays. Conclusion: The current study demonstrates that topical heparin can improve clinical outcomes in the treatment of burn injury.