Formulation & InVitro Evaluation of Controlled Release Tablets of Oxcarbazepine | Zendy

N.Phrudvish | Zendy; T. Malyadri | Zendy; Saibabu Ch | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Formulation & InVitro Evaluation of Controlled Release Tablets of Oxcarbazepine

Author(s) -

N.Phrudvish,

T. Malyadri,

Saibabu Ch

Publication year - 2021

Publication title -

international journal of indigenous herbs and drugs

Language(s) - English

Resource type - Journals

ISSN - 2456-7345

DOI - 10.46956/ijihd.vi.161

Subject(s) - oxcarbazepine , xanthan gum , chemistry , drug , chromatography , polymer , dissolution , controlled release , pharmacology , materials science , organic chemistry , medicine , carbamazepine , rheology , composite material , psychiatry , epilepsy

The present research project aimed to develop a Control release oral Oxcarbazepine tablets by using Polymers like Tamarind gum, Xanthan gum, HPMC K4M, and HPMC K 15M were used for controlling the drug release, and the polymers are mixed in a predetermined ratio. Totally 12 formulations were prepared and evaluated for pre-compression and post-compression parameters, and all the results were found to be within the limits. From the drug and excipients compatibility studies(FT-IR) it was confirmed that the drug and excipients have any interactions. The in vitro dissolution studies revealed that the F12 formulation containing 18% of HPMC K4M & 18% of HPMC K15M controls the drug release up to 12hours. So F12 formulation was considered to be suitable for the formulation of Oxcarbazepine controlled-release tablets at 18% concentration of HPMC K4M & 18% concentration of HPMC K15M and the drug release kinetics revealed that the F12 formulation shows a super case II transport mechanism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research