Open AccessFormulation & InVitro Evaluation of Controlled Release Tablets of Oxcarbazepine
Author(s) -
N.Phrudvish,
T. Malyadri,
Saibabu Ch
Publication year - 2021
Publication title -
international journal of indigenous herbs and drugs
Language(s) - English
Resource type - Journals
ISSN - 2456-7345
DOI - 10.46956/ijihd.vi.161
Subject(s) - oxcarbazepine , xanthan gum , chemistry , drug , chromatography , polymer , dissolution , controlled release , pharmacology , materials science , organic chemistry , medicine , carbamazepine , rheology , composite material , psychiatry , epilepsy
The present research project aimed to develop a Control release oral Oxcarbazepine tablets by using Polymers like Tamarind gum, Xanthan gum, HPMC K4M, and HPMC K 15M were used for controlling the drug release, and the polymers are mixed in a predetermined ratio. Totally 12 formulations were prepared and evaluated for pre-compression and post-compression parameters, and all the results were found to be within the limits. From the drug and excipients compatibility studies(FT-IR) it was confirmed that the drug and excipients have any interactions. The in vitro dissolution studies revealed that the F12 formulation containing 18% of HPMC K4M & 18% of HPMC K15M controls the drug release up to 12hours. So F12 formulation was considered to be suitable for the formulation of Oxcarbazepine controlled-release tablets at 18% concentration of HPMC K4M & 18% concentration of HPMC K15M and the drug release kinetics revealed that the F12 formulation shows a super case II transport mechanism.