Open AccessBoth sides of the story How bacteria transfer through the blood–brain barrier?
Author(s) -
Adrian Macion
Publication year - 2021
Publication title -
south florida journal of development
Language(s) - English
Resource type - Journals
ISSN - 2675-5459
DOI - 10.46932/sfjdv2n3-066
Subject(s) - transcellular , paracellular transport , blood–brain barrier , biology , bacteria , sepsis , mechanism (biology) , central nervous system , microbiology and biotechnology , immunology , neuroscience , permeability (electromagnetism) , epistemology , membrane , philosophy , genetics
Infections of central nervous system (CNS) still represent an important cause of mortality although globally abundance of antibiotics usage. Sepsis, bacterial invasion and microbial transversal of the Blood–Brain Barrier (BBB) are required to infect CNS. The latest research showed up that bacterial translocation through the BBB includes cytoskeleton rearrangements. Three different mechanism were described: paracellular, transcellular and Trojan-horse mechanism (in phagocytes). The consequences may be dramatic – disruptions of structure and loss of functionality of the BBB causing increased permeability, inflammatory and encephalopathy. Further experimental research should lead us to gain complete understanding of the host-bacteria interaction within microbial transversal of the BBB.