Thyrotoxicosis. Clinical recommendations for diagnosis and treatment Part І

Background. Currently submitted an increased rate of thyrotoxicosis, which is characterized by polyetiology, a variety of clinical manifestations and potential treatments. Appropriate treatment requires an accurate diag­nosis and depends on the comorbidities and preferences of the patient. The aim of the study was to consider the pathogenesis, clinical picture and di­agnosis of thyrotoxicosis. Purpose. To highlight the key points of clinical guidelines on thyrotoxi­cosis diagnosis and treatment provided by the American Thyroid Associa­tion and the American Association of Clinical Endocrinologists, US En­docrine Society dealing with diagnosis and treatment of thyroid diseases as well as the local clinical protocols of SO «Grigoriev Institute for Med­ical Radiology and Oncology of the National Academy of Medical Sci­ences of Ukraine». Materials and methods. Based on the research in the electronic databases of last 5 years publications, which are included in the Cochrane Library, PUBMED and MEDLINE databases. Clinical guidelines are based on expert consensus and assessing the significance according to the interna­tional guideline of thyrotoxicosis. Conclusions. Thyrotoxicosis treatment remains a challenging is­sue of modern internal medicine. Despite the existing numerous clini­cally proven protocols for the treatment of this pathology, the comorbid background of patients complicates following them. The implementa­tion of the provided protocol elements will make it possible to introduce the principles of a customized approach in thyrotoxicosis patients.