Open AccessA Short Review on Application of Liquisolid Technology
Author(s) -
Shaveta Sharma,
Divya Sharma,
Jyoti Singh
Publication year - 2021
Publication title -
cgc international journal of contemporary technology
Language(s) - English
Resource type - Journals
ISSN - 2582-0486
DOI - 10.46860/cgcijctr.2021.12.31.276
Subject(s) - solubility , bioavailability , dissolution , chemistry , aqueous solution , water soluble , salt (chemistry) , materials science , chemical engineering , chromatography , organic chemistry , pharmacology , medicine , engineering
In this paper we have surveyed about formulation and evaluation of Liquisolid formulations and its work in antidiabetics . Mostly poorly water soluble drugs are in research category despite of less dissolution rate and poor bioavailability. Solubility is a vital parameter to develop new formulation as industries faced serious issue regarding the poor aqueous solubility of the drugs. Various methods for solubility enhancement include modifications of the drug, involvement of co-solvents, complexation, salt formation, size reduction. A propitious technique to solve major challenges like solubility, dissolution rate and their bioavailability. This technique can be defined as the conversion of poorly soluble liquid medications into non-adherent, dry, compressible and free flowing powder mixtures with help of excipients. Many anti-diabetic drugs are belonging to BCS Class-II facing challenges like solubility and bioavailability.