Open AccessThe Influence of Orally Given Lead Acetate on the Expression of TNF-α and IL-6 of Fallopian Tube Epithel Cell of the Wistar Female Rat (Rattus Norvegicus)
Author(s) -
SST Fany Yanuarti,
M.Kes Dr. Setyawati Soeharto
Publication year - 2019
Publication title -
international journal of research in informative science application and techniques
Language(s) - English
Resource type - Journals
ISSN - 2581-5814
DOI - 10.46828/ijrisat.v3i3.69
Subject(s) - lead acetate , body weight , fallopian tube , significant difference , andrology , biology , physiology , immune system , medicine , tumor necrosis factor alpha , endocrinology , immunohistochemistry , zoology , immunology , anatomy , toxicity
Objective: This research aims at proving the influence of orally give lead acetate on TNF-α and IL-6 of fallopian tube epithel cell of The Wistar Female Rat (Rattus Norvegicus).
Method: Using true experimental post only control group method, there were 24 Wistar female rat (Rattus Norvegicus) with age of 10-12 weeks and body weight of 100-200 grams. The 24 rats were divided into 4 groups consisting of 1 control grup and 3 d groups with lead dosage of 30, 100, and 300 ppm. The lead was given with sonde for 30 days.The body weight and the fallopian tube weight of the rat were weighed, and expression of TNF-α and IL-6 with immune histochemistry.
Result: There were significant decrease of body weight difference of the treated groups compared with the control group, significant increase of TNF-α expression on the dosage of 30 ppm and 100 ppm and statistically insignificant increase of IL-6 with dosage of 300 ppm.
Conclusion: The lead given orally can increase the expression of TNF-α and IL-6 of the fallopian tube epithel.