Open AccessMECHANISMS OF MORPHOLOGY DEATH OF TUMOR CELL BY EFFECT NON-RADIOACTIVE AND RADIOACTIVE 195mPt-CISPLATIN
Author(s) -
N.P. Dikiy,
Yu.V. Lyashko,
Е.П. Медведева,
D. V. Medvedev
Publication year - 2021
Publication title -
problems of atomic science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.216
H-Index - 17
eISSN - 1562-6016
pISSN - 1682-9344
DOI - 10.46813/2021-133-123
Subject(s) - cisplatin , programmed cell death , apoptosis , cancer research , necrosis , chemistry , radiochemistry , nuclear medicine , medicine , pathology , chemotherapy , biochemistry
The photonuclear technology of preparation radioactive cisplatin 195mPt was been developed by the bremsstrahlung from the electron accelerators. In the novel technology, the production of 195mPt from reaction 197Au(γ,np)195mPt with a high specific activity >1 Ci/mg-1 was realized. The Ehrlich adenocarcinoma cells were been used as a neoplastic model. There are two groups: 1. tumor cells with non-radioactive cisplatin; 2. tumor cells with radioactive cisplatin (0.17 pg 195mPt-cisplatin). The number of morphology death cells as a result of radioactive cisplatin action was more than after action of non-radioactive cisplatin. The different mechanisms of the morphology death cell (necrosis for non-radioactive and apoptosis for radioactive) were detected.