Open AccessExperience in the Surgical Management of Two Cases with Acromegaly
Author(s) -
Eka Julianta Wahjoepramono
Publication year - 2021
Publication title -
jurnal ilmu bedah indonesia/ropanasuri
Language(s) - English
Resource type - Journals
eISSN - 2723-7494
pISSN - 0216-0951
DOI - 10.46800/jibiikabi.v35i2.131
Subject(s) - acromegaly , medicine , incidence (geometry) , pituitary adenoma , growth hormone , radiation therapy , disease , adenoma , presentation (obstetrics) , hormone , surgery , physics , optics
Acromegaly is a chronic disorder that usually develops over many years due to long term exposure to elevated levels of growth hormone (GH) most typically caused by a somatotrophic cell pituitary adenoma. It has an annual incidence of approximately 3-4 cases / million. A diagnosis of acromegaly is made based on the clinical presentation, biochemical and radiologic finding. The classical feature is the change in appearance and acral enlargement. No single therapy is comprehensively successful in controlling the disease. Surgical, medical and radiation treatments are available for lowering GH and insulin-like growth factor I (IGF-I) hypersecretion, controlling pituitary tumor mass effects, and lowering morbidity.