Open AccessControlled release miglitol microspheres formulation development and evaluation
Author(s) -
Prasanna Kumari K,
V Jhansi Priya Marabathuni,
Naidu Narapusetty
Publication year - 2022
Publication title -
international journal of pharmacognosy and chemistry
Language(s) - English
Resource type - Journals
ISSN - 2582-7723
DOI - 10.46796/ijpc.v3i1.260
Subject(s) - microsphere , polymer , chemistry , fourier transform infrared spectroscopy , cellulose , chemical engineering , nuclear chemistry , organic chemistry , engineering
The research explain about Miglitol site in the body and also to achieve and maintain the desired ISD concentration, having 2 hour half-life and low bioavilability. The paper give information about nine formulations formulated by using HPMC K15M, Ethyl cellulose and karaya gum in different proportions. The FTIR Spectra revealed that, there was no interaction between polymers and Miglitol. As the polymer ratio was increased, the mean particle size of Miglitol microspheres was also increased. From the results it can be inferred that there was a proper distribution of Miglitol in the microspheres and the deviation was within the acceptable limits. On the basis of release data and graphical analysis formulation F6 containing HPMC K15M showed a good controlled release profile up to 12hrs with maximum entrapment efficiency because of high polymer concentration and follows zero order kinetics with super case II transport mechanism.