Open AccessFormulation and Invitro Characterization of Fluvoxamine Loaded Nanoparticles
Author(s) -
S Naga Durga Mani Achyuth,
T. Malyadri
Publication year - 2021
Language(s) - English
Resource type - Journals
ISSN - 2582-7499
DOI - 10.46795/ijhcbs.vi.160
Subject(s) - fluvoxamine , zeta potential , drug , pharmacology , chemistry , serotonin reuptake inhibitor , drug delivery , ethyl cellulose , nanoparticle , nanotechnology , materials science , serotonin , polymer , medicine , biochemistry , organic chemistry , fluoxetine , receptor
Fluvoxamine is an antidepressant that functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. As the biological half-life of the drug is 15.6 hrs and belongs to BCS class II. To overcome these problems, Nanoparticles of Fluvoxamine were formulated by using Ethyl Cellulose, Eudragit RS 100 & Eudragit Rl 100 as a polymer by emulsification method. Among all the 9 formulations F6 formulation is optimized, as it shows maximum drug release at the end of 12hrs which suits the controlled release drug delivery system criteria as per our studies, having acceptable particle size, SEM, and Zeta potential value. From the drug release kinetics of the F8 formulation of Losartan Nanoparticles dispersion, it was concluded that the F8 formulation follows Zero-order drug release with super case II transport mechanism.