Open AccessКOMPLEKSI ZLATA KAO POTENCIJALNI SUPLEMENTI SA ANTIKANCEROGENIM I ANTIVIRUSNIM DELOVANJEM
Author(s) -
Marko Antonijević,
Jelena Đorovic Jovanovic,
A. Kesic,
Dejan Milenković,
Zoran Marković
Publication year - 2021
Publication title -
zbornik radova
Language(s) - English
Resource type - Conference proceedings
eISSN - 2683-5649
pISSN - 2560-550X
DOI - 10.46793/sbt26.429a
Subject(s) - platinum , combinatorial chemistry , chemistry , anticancer drug , stereochemistry , pharmacology , phenanthroline , medicinal chemistry , medicine , drug , biochemistry , organic chemistry , catalysis
The pharmacologic properties of gold compounds have been known since the end of the 19th century. They have been used for different studies, even though they are usually used for the treatment of arthritis. In the last decade, gold complexes have received increased attention due to the variety of their applications. Primary, they have been investigated as potential anticancer and chemotherapeutic agents. It is well known that gold(III) complexes are very similar to platinum(II) compounds, so they could exhibit prospective anticancer, cytotoxic and antitumor properties. In this paper, were investigated the interactions of the gold(III) complexes, [Au(DPP)Cl2]+ and [Au(DMP)Cl3] where DPP=4,7-diphenyl-1,10-phenanthroline and DMP=2,9-dimethyl-1,10-phenanthroline) with SARS-CoV2 protease. The obtained results indicate that the square-planar [Au(DPP)Cl2]+ complex shows good inhibitory activity, compared to FDA approved drugs, cinanserin and chloroquine.