Open AccessCARDIOVASCULAR EFFECTS OF VASOACTIVE SUBSTANCES IN PROLONGED ANESTHESIA IN DOGS
Author(s) -
Ljubica Spasojević Kosić,
Dragiša Trailović
Publication year - 2012
Publication title -
arhiv veterinarske medicine/archives of veterinary medicine
Language(s) - English
Resource type - Journals
eISSN - 2683-4138
pISSN - 1820-9955
DOI - 10.46784/e-avm.v5i1.159
Subject(s) - vasoactive , blood pressure , histamine , medicine , anesthesia , heart rate
Knowledge of the influence of anesthesia in anesthetized animals at in vivo experiments is essential in order to interpret the results of investigations properly and correctly. In this study we researched cardiovascular effects of vasoactive substances (adrenalin, noepinephrine, dimethylphenylpiperazinium, acethylholin, histamine) in prolonged anesthesia of six hours in dogs. The cardiovascular effects of vasoactive substances were evaluated by direct blood pressure measurement, ecg monitoring and urine output measurement. The dose-effect curve of systolic (SAP) and diastolic (DAP) blood pressure were obtained for each of the vasoactive substances. The differences between cardiovascular effects of vasoactive substances at the beginning and at the end of prolonged anesthesia were tested. There were statistically significant differences (p<0.05) in changes of blood pressure at the beginning and at the end of prolonged anesthesia only for some doses of adrenalin and histamine (1 mg/kg and 3 mg/kg). No significant changes in heart rhythms at the beginning and at the end of prolonged anesthesia were recorded. The urine output during anesthesia depended on applied vasoactive substances.