Open AccessAcute and Chronic Graft-Versus-Host-Disease – A Focus on Pediatric Patients
Author(s) -
Antônio Vaz de Macedo,
José Nivaldo Garcia,
Roseane Vasconcelos Gouveia,
Rita de Cássia Tavares
Publication year - 2021
Publication title -
journal of bone marrow transplantation and cellular therapy
Language(s) - English
Resource type - Journals
ISSN - 2675-374X
DOI - 10.46765/2675-374x.2021v2n4p140
Subject(s) - medicine , hematopoietic stem cell transplantation , disease , graft versus host disease , transplantation , intensive care medicine , bone marrow transplantation , bone transplantation , refractory (planetary science) , population , immunology , pediatrics , surgery , physics , environmental health , astrobiology
Graft-versus-host disease (GVHD), either in its acute or chronic form, is the main contributory factor for morbidity and non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recent advancements in the classification of this disease, with better applicability and reproducibility of standardized criteria, coupled with improvements in the management of steroid-refractory or resistant cases, have led to promising results. In 2020, the Brazilian Group for Pediatric Bone Marrow Transplantation of the Brazilian Society for Blood and Marrow Transplantation and Cellular Therapy (SBTMO) convened a task force to provide updated, evidence-based guidance for the diagnosis, classification, staging, prophylaxis, and treatment of GVHD, with a focus on the pediatric population, the results of which are presented here.