Open AccessPHYSICOCHEMICAL CHARACTERIZATION OF QUERCETIN-LOADED LIPOSOMES PREPARED BY SONICATION FOR FUNCTIONAL FOOD APPLICATION
Author(s) -
Nur Amalina Ramli,
Nora’aini Ali,
Sofiah Hamzah
Publication year - 2020
Publication title -
journal of sustainability science and management/journal of sustainability science and management
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.175
H-Index - 14
eISSN - 2672-7226
pISSN - 1823-8556
DOI - 10.46754/jbsd.2020.08.002
Subject(s) - sonication , liposome , nanocarriers , zeta potential , quercetin , phospholipid , phosphatidylcholine , bioavailability , chemistry , chromatography , dispersity , bilayer , materials science , chemical engineering , nanotechnology , drug delivery , nanoparticle , organic chemistry , membrane , biochemistry , antioxidant , pharmacology , medicine , engineering
This research was intended to synthesize liposome as a nanocarrier to encapsulate quercetin, which is prone to degradation and susceptible to low bioavailability upon oral administration. The liposomes were synthesized by thin-film hydration method and followed by probe sonication for downsizing. Soy phosphatidylcholine (SPC) and cholesterol (CHOL) were employed as the composition of the phospholipid bilayer. Results indicated a dependence of sonication amplitude and time in the formation of free liposomes (FL). The average size of quercetin-loaded liposomes (QL) prepared was 346.4 nm with a narrow polydispersity index (0.22) and a high magnitude of zeta potential (-49.6 mV). These characterizations depict that a homogenous nanovesicle suspension with high stability was successfully synthesized. Quercetin was incorporated into the liposomes with a high encapsulation efficiency of 90.7% and loading capacity of 9.3%. This viable nanocarrier perhaps will provide ingenious protection for a wider spectrum of active agents in food and biopharmaceutical products.