Open AccessFormulation and Evaluation of Mouth Dissolving Tablet of Almotriptan Malate
Author(s) -
Ashish Gupta,
Mahajan Mahesh,
Surabhi Dudhe Pravin,
Richa Sharma,
K M Sweta,
Darwhekar Gajanan
Publication year - 2021
Publication title -
american journal of pharmtech research
Language(s) - English
Resource type - Journals
ISSN - 2249-3387
DOI - 10.46624/ajptr.2021.v11.i5.00610.46624/ajptr.2021.v11.i5.006
Subject(s) - croscarmellose sodium , friability , dissolution , pharmacology , chromatography , chemistry , bitter taste , saliva , sodium , first pass effect , taste , materials science , medicine , drug , food science , dosage form , biochemistry , organic chemistry , magnesium stearate
Mouth dissolving tablet disintegrates and dissolves rapidly in the saliva, within a few seconds without the need of drinking water or chewing. A mouth dissolving tablet usually dissolves in the oral cavity within 15 seconds to 3 minutes. Almotriptan malate is an anti migraine drug with bitter taste and shows hepatic metabolism. In the present work, Mouth dissolving tablets of almotriptan malate were prepared by direct compression method using sodium starch glycolate and croscarmellose sodium as superdisintegrant with a view to enhance patient compliance and to avoid gastric dysmotility which is common with migraine drugs and for fast action of drug. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water-absorption ratio and in-vitro dispersion time. Short-term stability studies on the promising formulation indicated that there are no significant changes in drug content and disintegration time. Keywords: Almotriptan malate, Superdisintegrant, Sodium starch glycolate, Crosscarmellose sodium, Taste masking.