Open AccessANTIRADICAL ACTIVITY OF 1,4-AND 1,2-BENZENE DICARBOXYL ESTERS FROM DEINBOLLIA PINNATA LEAVES
Author(s) -
Yakubu Rufai,
Norazah Basar,
Sheela Chandren,
Kolawole Yusuf Suleiman,
I. Yinusa
Publication year - 2020
Publication title -
bulletin of the chemical society of nigeria
Language(s) - English
Resource type - Journals
ISSN - 0795-2066
DOI - 10.46602/jcsn.v45i6.563
Subject(s) - dpph , abts , chemistry , benzene , ferric , antioxidant , nuclear chemistry , sapindaceae , methanol , scavenging , organic chemistry , botany , biology
The family Sapindaceae are tropical and sub-tropical continental plants. In this study, 1,4-Benzene dicarboxyl ester (1) and 1,2-Benzene dicarboxyl ester (2) from methanolic extracts of Deinbollia pinnata leaves. The successful separation of the isomeric mixture is by freezing the sub-fraction with methanol for seventy-two hours; followed by filtration, isolation and purification. The compounds were characterized spectroscopically (1H &13C NMR, FTIR and GC-MS). The methanolic extracts showed good DPPH scavenging activity with percentage inhibition greater than 70% at 125 ppm, an excellent antioxidant activity towards ABTS assay with the IC50 value of 13.68 µg/mL and also exhibits most potent ferric ion reducer at 3.45 ± 1.30 mM FRAP equivalent compared to other extracts. The 1,4-Benzene dicarboxyl ester (1) displayed high antioxidant radical scavenging activity towards DPPH assay with IC50 value of (IC50 32.99; 73.491%) and 1,2-Benzene dicarboxyl ester (2) at (IC50 33.99; 71.11%);ABTS activity with SC50 value at 48.81µg/mL; 87.98% (1) and 49.55µg/mL; 83.85% (2) and a good potential as ferric ion reducer ranging from 0.05±0.00 to 1.37±0.02 (1) and 0.16±0.04 to 1.29±0.03 (2) mM FRAP equivalent respectively.