Open AccessTANGO-2 with Severe and Prolonged Rhabdomyolysis in a 2-year Old Male with Human metapneumovirus Infection. A case report and literature review.
Author(s) -
Rowida Kheireldin,
Sameer Imdad,
Waseem Ostwani
Publication year - 2020
Publication title -
translation
Language(s) - English
Resource type - Journals
ISSN - 2469-6706
DOI - 10.46570/utjms.vol7-2020-389
Subject(s) - rhabdomyolysis , medicine , acute kidney injury , human metapneumovirus , creatinine , creatine kinase , urine , respiratory system , respiratory tract infections
We report a unique case of prolonged acute rhabdomyolysis in a 2-year-old male with known TANGO-2 mutation with delayed peak in creatinine kinase levels secondary to human metapneumovirus infection. Creatinine kinase peaked at 424,760 U/l on day 9 of hospitalization. Resolution of rhabdomyolysis was achieved using aggressive management with intravenous fluids with optimal urine output and no kidney injury. TANGO-2 patients may develop severe and prolonged rhabdomyolysis with a delayed peak suggesting the need for prolonged inpatient hospitalization to prevent life-threatening complications.