Open AccessThe biological action of solid solutions (on the example of cadmium-mercury-tellurium alloy)
Author(s) -
N. I. Nikolaeva,
А. С. Филин,
Ekaterina A. Guseva,
Lubov’ G. Ivanova
Publication year - 2020
Publication title -
zdravoohranenie rossijskoj federacii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.164
H-Index - 3
eISSN - 2412-0723
pISSN - 0044-197X
DOI - 10.46563/0044-197x-2020-64-3-158-162
Subject(s) - inhalation , acute toxicity , chemistry , toxicology , inhalation exposure , cadmium , physiology , pharmacology , toxicity , environmental chemistry , medicine , biology , anesthesia , organic chemistry
Solid solutions are widely used in various industries. Experimental studies have been conducted to study the biological effects of warm-blooded animals (rat, mouse) solid solution based on cadmium (7%) mercury (52%) and tellurium (41%) (CMT). The purpose of the study: To investigate the biological effect of the solid solution (CMT) on the body of experimental animals. Material and methods. On the models of acute and subchronic exposure, the biological effect of CMT on the organism of warm-blooded animals (rats, mice) was evaluated. Studies have been carried out to establish toxicometry parameters (acute toxicity, the threshold for acute inhalation and intragastric effects, cumulative properties). In subchronic experiments, local and general toxic effects were investigated. The work used biochemical, physiological, toxicological, pathomorphological, statistical research methods. Results. According to acute experiments, the investigated substance belongs to the 4th hazard class (low-hazard compound). The threshold of acute inhalation action for rats is 46.20 mg/m3, and the intragastric effect for rats is 5000 mg/kg. CMT has moderate cumulation (Kcum = 4.79), does not irritate the skin. The compound was found to have a general toxic effect, which is based on functional disorders of the nervous system, liver, and kidneys. Discussion. The results of the study indicate that solid CMT solution has a polytropic effect on the warm-blooded organism. Conclusion. With prolonged exposure, the CMT aerosol can harm the body of workers, it is necessary to provide general preventive measures that prevent the aerosol of solid solutions from entering the body: automation, mechanization, sealing of production, adequate ventilation of production rooms, the use of personal protective equipment, the passage of mandatory periodic medical examinations by workers, and monitoring the concentration of CMT in the air of the working area should be carried out according to the MPC - 1.0 mg / m3 (mercury vapor).