Open AccessHETEROTRANSPLANTATIONS AND GENOMIC IN CANCER RESEARCH
Author(s) -
Michel Leclerc
Publication year - 2021
Publication title -
american international journal of cancer studies
Language(s) - English
Resource type - Journals
eISSN - 2641-5674
pISSN - 2641-5658
DOI - 10.46545/aijcs.v3i1.220
Subject(s) - hela , cytotoxicity , immune system , plasmid , cancer cell , tumor cells , gene , microbiology and biotechnology , cancer research , biology , genetic enhancement , transfection , cancer , virology , chemistry , cell culture , immunology , in vitro , genetics
We performed ,in 1975, the first heterotransplantation of invertebrate A.O in nude mouse, then a double heterotransplantation of human tumor and Axial organ next to this last one, always in nude mouse: The human tumor was rejected in 50% of observed cases. Some years later, we found that A.O cells exerted an induced and spontaneous cytotoxicity against SP2 and MBL2 mouse tumoral cells. Recently, we discovered a sea star Igkappa gene with immune properties. This gene was inserted in a CMV(cytomegalovirus) and finally in a plasmid called « young » plasmid.The induced« young » protein exerted a spontaneous cytotoxicity against osteosarcom cells (U2oS cells) against A-375 melanome cells and Hela cells