Open AccessPhytochemical screening and antidiabetic activities test of ethanol extract from Syzygium cumini L. seeds in male Wistar rats induced by alloxan
Author(s) -
Lia Puspitasari,
Made Asmarani Dira
Publication year - 2022
Publication title -
pharmacy education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 17
eISSN - 1477-2701
pISSN - 1560-2214
DOI - 10.46542/pe.2022.222.165168
Subject(s) - phytochemical , syzygium , traditional medicine , alloxan , glibenclamide , polyphenol , chemistry , ethanol , saponin , blood sugar , sugar , diabetes mellitus , food science , antioxidant , biochemistry , medicine , alternative medicine , endocrinology , pathology
The ethanol extract of the jamblang fruit seed (Syzygium cumini L.) is known to have an antidiabetic effect and this is further confirmed by the high intensity of its α-amylase inhibitory effect. Aim: The purpose of this study was to determine the antidiabetic activity of jamblang fruit seed extract in reducing blood sugar levels.Method: Phytochemical screening was carried out on the ethanol extract from jamblang fruit seeds. Twenty-eight male wistar rats were given alloxan to induce diabetes. The rats were divided into four groups: normal control, negative control (CMC-Na), positive control (Glibenclamide), and a group that was given ethanol extract of jamblang seeds. Measurement of blood glucose levels was carried out on day 0 and day 15. Results: The phytochemical screening results show that the ethanolic extract of jamblang fruit seeds (Syzygium cumini L.) contains alkaloids, flavonoids, saponins, tannins, and polyphenols, as well as steroids and triterpenoids. The group being treated with ethanol extract from jamblang seeds showed decreased blood sugar levels on day 15, indicating the antidiabetic effectiveness of the extract. Conclusion: Ethanol extract from jamblang seeds (Syzygium cumini) contains alkaloids, flavonoids, saponins, tannins, polyphenols, steroids, and triterpenoids; and is able to reduce blood glucose levels of male wistar rats induced with alloxan.