Open AccessDissolution profile of Curcumin from solid dispersion prepared at a high drug load of Curcumin using Poloxamer 407 as the carrier
Author(s) -
Dewi Setyaningsih,
Yustina Sri Hartini,
Christine Patramurti,
Sastira Putri,
Yosi Bayu Murti
Publication year - 2021
Publication title -
pharmacy education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 17
eISSN - 1477-2701
pISSN - 1560-2214
DOI - 10.46542/pe.2021.212.7780
Subject(s) - curcumin , dissolution , poloxamer , bioavailability , dispersion (optics) , poloxamer 407 , chemistry , chromatography , materials science , solvent , dissolution testing , chemical engineering , pharmacology , organic chemistry , medicine , biochemistry , physics , biopharmaceutics classification system , optics , copolymer , engineering , polymer
Curcumin, a BCS II drug, suffers from poor bioavailability. Increasing curcumin dissolution is a way to increase its bioavailability. Solid dispersion formulation can be used to improve curcumin dissolution. However, the successful curcumin solid dispersion is limited to a relatively low drug load (< 20%).Objective: This study aimed to investigate the dissolution behaviour of curcumin at a higher drug load (27.9%, 42.3%, and 56.6%) using a surfactant carrier of poloxamer 407. Methods: The solvent evaporation method was employed to prepare high drug load solid dispersion of curcumin. A physical mixture of the corresponding solid dispersion formulation was prepared as a control. Drug load, dissolution behaviour in 180 minutes, and dissolution efficiency (DE180) were determined. Results: The results showed that incorporating curcumin into a poloxamer 407 solid dispersion significantly improves the dissolution rate of curcumin. In the solid dispersion formula, the dissolution behaviour of curcumin was found to be carrier-dependent.