Open AccessAdverse drug reactions associated with successful treatment of multidrug-resistant tuberculosis patients in Cempaka Putih Islamic Hospital Central Jakarta
Author(s) -
Adin Hakim Kurniawan,
Harpolia Cartika,
Siti Aisyah
Publication year - 2021
Publication title -
pharmacy education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 17
eISSN - 1477-2701
pISSN - 1560-2214
DOI - 10.46542/pe.2021.212.1521
Subject(s) - medicine , tuberculosis , drug , incidence (geometry) , adverse drug reaction , adverse effect , drug reaction , chi square test , retrospective cohort study , population , intensive care medicine , pharmacology , pathology , statistics , physics , mathematics , environmental health , optics
Indonesia experiences Tuberculosis (TB) cases that are very complex and complicated, especially those dealing with Multi-Drug Resistance TB (MDR-TB). Its therapy using several types of drugs can cause several problems; one of them is an adverse drug reaction. Aim: To investigate the association between Adverse Drug Reactions (ADR) and the successful treatments of MDR-TB patients. Method: This was a retrospective study, the population in this study were all patients with medical and treatment records for MDR-TB. This sampling type is a purposive sampling technique. The statistical analysis used the chi-square test as the statistical test. Results: The significant correlation was between the incidence of ADRs and successful treatment with p=0.024; odd ratio=2.526; CI=1.193 - 17.892. Conclusions: This study may help in formulating strategies for the timely and aggressive management of adverse drug reactions. This can reduce the deferral of therapy and increase the clinical success rate.