Open AccessCorrelation between the antioxidant capacity of plasma and blood glucose level
Author(s) -
Eva Nurinda,
Emelda,
Nurul Kusumawardani
Publication year - 2021
Publication title -
pharmacy education
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.198
H-Index - 17
eISSN - 1477-2701
pISSN - 1560-2214
DOI - 10.46542/pe.2021.212.108115
Subject(s) - glibenclamide , tinospora cordifolia , antioxidant capacity , antioxidant , diabetes mellitus , traditional medicine , curcuma , oxidative stress , kowsar , medicine , blood sugar , pharmacology , chemistry , endocrinology , biochemistry
Oxidative stress on tissues can cause diseases such as diabetes mellitus (DM).Aim: This study aimed to pharmacologically evaluate the decrease in blood glucose levels and its relationship with the total antioxidant capacity of the blood compared to glibenclamide.Method: An experimental study with completely randomised designs was carried out. Rats were induced with streptozotosin followed by ethanolic extract for ten days. Results: The One-Way Anova test, showed that the increase of the total antioxidant capacity of plasma treated with ethanolic extract of Tinospora cordifolia and Curcuma zanthorrhiza was comparable in the same amount to glibenclamide (p=0.345), (p=0.289). There was a relationship between total blood antioxidant capacity and blood glucose levels, this linear association was expressed with the following mathematical equation: y = 20,253 - 2,946x. Conclusion: The antioxidant content of Tinospora cordifolia, Curcuma zanthorrhiza, and Cinnamomum verum has the potential to control blood glucose in diabetes mellitus.