Open AccessBeryllium Induced Biochemical Alterations in Rodent Model and its Treatment with Calcium Salt of Diethylene Triamine Penta Acetic Acid with α -tocopherol
Author(s) -
Anil K. Mishra
Publication year - 2020
Publication title -
international journal of modern trends in science and technology
Language(s) - English
Resource type - Journals
ISSN - 2455-3778
DOI - 10.46501/ijmtst061025
Subject(s) - chemistry , toxicity , tiron , tocopherol , calcium , pharmacology , antidote , biochemistry , alkaline phosphatase , lipid peroxidation , oxidative stress , nuclear chemistry , vitamin e , antioxidant , medicine , organic chemistry , enzyme , superoxide
To evaluate therapeutic efficacy of chelating agents tiron (Sodium-4,5- dihydroxy-1,3-benzenedi-sulphonate) and CaNa3DTPA (Calcium tri-sodium di-ethylene tri-amine penta acetic acid) in presence ofα-tocopherol against beryllium induced toxicity, adult female albino rats were exposed to beryllium nitrate for28 days followed by therapy with tiron (471 mg/kg, ip) and CaNa3DTPA (35 mg/kg, ip) alone and incombination with α-tocopherol (25 mg/kg, po). Results revealed non-significant fall in hemoglobin and totalserum protein content while significant fall in blood sugar level and activity of serum alkaline phosphatase.On the other hand, significant rise in the activity of serum transaminases and LDH was noticed afterberyllium administration. Significant increase in total and esterified cholesterol was found in liver andkidney after toxicity. Significant increase in lipid peroxidation and decreased level of reduced glutathione inboth the organs showed oxidative stress due to beryllium exposure. CaNa3DTPA showed moderatetherapeutic efficacy; however, its effectiveness was enhanced with α-tocopherol to some extent. Tiron incombination with α-tocopherol exerted statistically more beneficial effects in reversal of beryllium inducedbiochemical alterations.