Open AccessRemoval of Mefenamic Acid from Aqueous Solution by Fenton Process: Optimization Using Response Surface Methodology with Central Composite Design
Author(s) -
R. Deepa,
G. M. Madhu,
Roy M. Thomas,
V. Sivanandan Achari
Publication year - 2021
Publication title -
nature, environment and pollution technology/nature, environment and pollution technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.154
H-Index - 11
eISSN - 2395-3454
pISSN - 0972-6268
DOI - 10.46488/nept.2021.v20i05.023
Subject(s) - mefenamic acid , central composite design , response surface methodology , aqueous solution , chemistry , composite number , box–behnken design , process optimization , chromatography , industrial and production engineering , nuclear chemistry , chemical engineering , materials science , composite material , organic chemistry , engineering , electrical engineering
In the present study, the three main process parameters in the Fenton process for the removal of pharmaceutical compound Mefenamic acid from an aqueous solution were optimized using response surface methodology (RSM). Central composite design (CCD) was used for process optimization. The primary and secondary interaction effects of the selected parameters such as H2O2, Fe2+ and pH on the removal of mefenamic acid were examined. A mathematical model for the removal process based on the selected variables was developed. The interaction effect between the chosen parameters shows that the removal of mefenamic acid was enhanced in the acidic pH range at a high concentration of H2O2 and in a medium concentration level of the catalyst Fe2+. The removal efficiency of 81.24% was obtained for mefenamic acid at the optimized condition of variables such as 9.36 mM H2O2, 0.058 mM Fe2+and at a pH value of 2.1.