Open AccessRecent advances on visual cycle protein research and progress on clinical translation
Author(s) -
Xin Yee Ooi,
Rujman Khan,
Anjalee Choudhury,
Francisco X. Elisarraras,
Jeff Grigsby,
Brandi Obregon,
Andrew Tsin
Publication year - 2020
Publication title -
scholarworks @ utrgv (the university of texas rio grande valley)
Language(s) - English
Resource type - Journals
eISSN - 2692-4331
DOI - 10.46439/ophthalmology.2.017
Subject(s) - translation (biology) , data science , computer science , biology , biochemistry , gene , messenger rna
Since the publication of our previous paper, Visual cycle proteins: Structure, function, and roles in human retinal disease (Tsin, et.al, JBC 293:13016, 2018) there has been significant progress on multiple topics discussed in this paper. In the present communication, we further explore research advances on two visual cycle proteins: DES1 and IRBP. In addition, we emphasize the progress of clinical translation of other visual cycle protein research, including the breakthrough of FDA-approved gene therapy for Leber's congenital amaurosis, and additional gene therapies at different stages of clinical trials for various retinal diseases such as retinitis pigmentosa, diabetic retinopathy, and Stargardt's disease.