Open AccessChallenges in the humanized mouse model for cancer: A commentary
Author(s) -
Eric G. RamírezSalazar,
Meenhard Herlyn,
Rajasekharan Somasundaram
Publication year - 2021
Publication title -
pubmed central
Language(s) - English
DOI - 10.46439/cancerbiology.2.022
Subject(s) - immune system , cytotoxic t cell , humanized mouse , immunology , biology , tumor microenvironment , human leukocyte antigen , disease , cancer research , medicine , antigen , in vitro , pathology , genetics
The complexity of the tumor microenvironment has been a challenge for understanding the mechanisms of therapy resistance. The development of improved animal models that closely mimic human disease is key for understanding and treating diseases. Recently, a new humanized mouse model has been developed that enables the study of human immune cells in tumor host-cell interactions. In this commentary we highlight the critical aspects of mast cells in immune therapy resistance. These mast cells release cytokines that downmodulate HLA class I on the malignant cells making them inaccessible the cytotoxic activity of T cells.