Open AccessMicrodose Flare-up Gonadotropin-releasing Hormone (GnRH) Agonist Protocol and GnRH Antagonist Protocol: Effects on In-vitro Fertilization in Patients with Poor-responder Diagnosis According to Bologna Criteria
Author(s) -
Gökşen Görgülü,
Merve Çakır Köle,
Oya Aldemir,
Emre Köle,
Serdar Dilbaz
Publication year - 2021
Publication title -
aegean journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
ISSN - 2717-6320
DOI - 10.46328/aejog.v3i2.84
Subject(s) - microdose , in vitro fertilisation , medicine , equine chorionic gonadotropin , gonadotropin releasing hormone , antral follicle , andrology , gonadotropin , gonadotropin releasing hormone agonist , leuprorelin , agonist , hormone antagonist , gynecology , human chorionic gonadotropin , antagonist , hormone , luteinizing hormone , biology , pregnancy , ovulation , receptor , genetics
Objective: The aim of the study was to evaluate microdose flare-up Gonadotropin-Releasing Hormone (GnRH) agonist protocol and GnRH antagonist protocol with respect to their effects on in-vitro fertilization (IVF) results in patients with poor ovarian response according to the Bologna Criteria.
Material Methods: This was a retrospective cohort study conducted in the Assisted Reproduction clinic of University of Health Sciences, Etlik Zübeyde Hanım Gynaecology Training and Research Hospital. A total of 645 patients who had been diagnosed as poor responders in our clinic, between 2007 and 2018, and received treatment with either microdose flare-up GnRH agonist protocol (n=250, 38.8%) or GnRH antagonist protocol (n=395, 61.2%), were included in the study.
Results: The mean age of the study group was 34.5±5.5 years. Comparisons showed that IVF cycle cancellation frequency (p<0.01), third day estradiol level (p=0.04) and third day follicle stimulating hormone level (p<0.01) were significantly greater in patients who underwent the microdose flare-up protocol. In the GnRH antagonist group, the number of surviving children (p=0.01), antral follicle count (p<0.01), follicle count on day of human chorionic gonadotropin (hCG) administration (p<0.01), endometrial thickness on hCG day (p<0.01), number of oocytes collected (p<0.01), mature oocyte count (p<0.01), embryo transfer number (p<0.01) were higher compared to the microdose flare-up protocol group. The two groups were similar in terms of clinical pregnancy rate.
Conclusions: In terms of clinical pregnancy rate, the IVF results of microdose flare-up and GnRH antagonist protocols are similar. Further studies are needed to reach more comprehensive results on the subject.