Open AccessA Robust Feature Extraction and Deep Learning Approach for Cancer Gene Prognosis
Author(s) -
Pinki Kumari,
J. Beatrice Seventline
Publication year - 2022
Publication title -
international journal of biology and biomedical engineering
Language(s) - English
Resource type - Journals
ISSN - 1998-4510
DOI - 10.46300/91011.2022.16.16
Subject(s) - python (programming language) , computer science , pattern recognition (psychology) , artificial intelligence , artificial neural network , standard deviation , feature extraction , mean squared error , data mining , mathematics , statistics , operating system
Mutated genes are one of the prominent factors in origination and spread of cancer disease. Here we have used Genomic signal processing methods to identify the patterns that differentiate cancer and non-cancerous genes. Furthermore, Deep learning algorithms were used to model a system that automatically predicts the cancer gene. Unlike the existing methods, two feature extraction modules are deployed to extract six attributes. Power Spectral Density based module was used to extract statistical parameters like Mean, Median, Standard deviation, Mean Deviation and Median Deviation. Adaptive Functional Link Network (AFLN) based filter module was used to extract Normalized Mean Square Error (NMSE). The uniqueness of this paper is identification of six input features that differentiates cancer genes. In this work artificial neural network is developed to predict cancer genes. Comparison is done on three sets of datasets with 6 attributes, 5 attributes and one attribute. We performed all the training and testing on the Tensorflow using the Keras library in Python using Google Colab. The developed approach proved its efficiency with 6 attributes attaining an accuracy of 98% for 150 epochs. The ANN model was also compared with existing work and attained a 10 fold cross validation accuracy of 96.26% with an increase of 1.2%.