Open AccessIn vitro antioxidant properties of 2-(4-(2-hydroxybenzylideneamino)benzylideneamino)benzoic acid
Author(s) -
Zehra Kübra Yılmaz,
Belma Asim,
Özlem Özdemir
Publication year - 2021
Publication title -
icontech journal of innovative surveys, engineering and technology
Language(s) - English
Resource type - Journals
ISSN - 2717-7270
DOI - 10.46291/icontechvol5iss3pp7-12
Subject(s) - dpph , chemistry , antioxidant , schiff base , ferrous , chelation , radical , nuclear chemistry , ic50 , organic chemistry , in vitro , polymer chemistry , biochemistry
In recent years, it has attracted great attention to determine and appraise synthetic antioxidants with high free radical scavenging capacity associated with various disorders. Because synthetic antioxidants are widely used in place of native antioxidants as they are influential and less expensive. In this study, the antioxidant activity of the newly synthesized asymmetric diimine Schiff base was determined by using DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, ferrous ion chelation (FIC) activity and total antioxidant activity (Phosphomolybdenum assay) methods. The effective concentration (IC50) values were calculated for the Schiff base and standards. According to the results of DPPH radical scavenging, ferrous ion chelation and total antioxidant methods, Schiff base showed a well antioxidant activity. It was determined that Schiff base is reactive towards DPPH radicals (IC50, 180.0 μM) and especially Fe+2 ions (IC50, 76.3 μM). It was also found that it actively reduces the Mo(VI) ion to the Mo(V) form (IC50, 121.5 μM). The our results indicate Schiff base, may be a fine candidate as a source of synthetic antioxidants and possibly strong drug.