Formulation and Optimization of Pulsatile Tablet for Circadian Rhythm of Blood Pressure

Circadian rhythm is a 24-hour cycle of human body, the body different aspect in the morning as compareto afternoon or night. The blood pressure rises in two time in a day, one is at early morning and second one is atevening.The aim of present project work was to design the pulsatile tablet for treatment of blood pressure withcombination drug therapy. in most cases it is seen that the increasing in Plasma norepinephrine level and plasmarenin activity in the morning; both hormones are potential to induce coronary vasoconstriction, therefore, there is aneed to a such formulation who achieve peak plasma concentration of drug at morning and can control morningspate of B.P. The pulsatile release of nebivolol after the lag time with sustain release of curcumin which maintainthe severity of blood Pressure. The Formulation of Core tablet of nebivolol was prepared by using superdisintegrate by direct compression with diluent. F10 batch was found to be optimized formulation as it shownpotent drug release within short time. The lag time was prolonged with an increase of the coating level, whereas thedrug release rate was almost constant, irrespective of the coating level the lag time of nebivolol was found to be 8 to8.5hrsand drug release after 9hrs. drug release was above 95% after lag time with constant release of curcumin.Hence, this approach can provide a useful means and may be helpful for patients with morning spate of BP anddevelopment of PDDS of combination drug therapy is a promising approach to overcome the side effect of singledrug i.e. nebivolol drug therapy and also oral drug delivery.