Review of Chemical, Pharmacological, Biological Activities of Isatin and its Derivatives – Part-1 (1877 to 2002)

:Isatin is a naturally occurring substance present in humans, animals, plants and coal tar. Isatinitself exhibits a variety of biological effects (invivo and invitro) and substituted isatins are reported topossess a wide range of pharmacological properties such as antimicrobial, antineoplastic, analgesic, antiinflammatory, antipyretic, enzyme activity, CNS activity, antiprotozoal, antihelminthic and association withbiomolecules. In this review article, we have attempted to compile the most signigicant reports (1877 to2002) of biological and pharmacological activites of isatin and its derivatives.