Open AccessCyclin A2: At the crossroads of cell cycle and cell invasion
Author(s) -
Abdelhalim Loukil
Publication year - 2015
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v6.i4.346
Subject(s) - microbiology and biotechnology , mitosis , rhoa , cyclin a , cyclin b , cell cycle , cytokinesis , polo like kinase , cyclin a2 , mitotic exit , biology , cyclin , cell division , cell , anaphase , signal transduction , genetics
Cyclin A2 is an essential regulator of the cell division cycle through the activation of kinases that participate to the regulation of S phase as well as the mitotic entry. However, whereas its degradation by the proteasome in mid mitosis was thought to be essential for mitosis to proceed, recent observations show that a small fraction of cyclin A2 persists beyond metaphase and is degraded by autophagy. Its implication in the control of cytoskeletal dynamics and cell movement has unveiled its role in the modulation of RhoA activity. Since this GTPase is involved in both cell rounding early in mitosis and later, in the formation of the cleavage furrow, this suggests that cyclin A2 is a novel actor in cytokinesis. Taken together, these data point to this cyclin as a potential mediator of cell-niche interactions whose dysregulation could be taken as a hallmark of metastasis.