Open AccessSignal transducer and activator of transcription 3 regulation by novel binding partners
Author(s) -
Tadashi Matsuda,
Ryuta Muromoto,
Yoshifumi Sekine,
Sumihito Togi,
Yuichi Kitai,
Shigeyuki Kawa,
Kenji Oritani
Publication year - 2015
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v6.i4.324
Subject(s) - stat3 , stat protein , pdz domain , crosstalk , signal transducing adaptor protein , signal transduction , microbiology and biotechnology , transcription factor , biology , genetics , gene , physics , optics
Signal transducers and activators of transcription (STATs) mediate essential signals for various biological processes, including immune responses, hematopoiesis, and neurogenesis. STAT3, for example, is involved in the pathogenesis of various human diseases, including cancers, autoimmune and inflammatory disorders. STAT3 activation is therefore tightly regulated at multiple levels to prevent these pathological conditions. A number of proteins have been reported to associate with STAT3 and regulate its activity. These STAT3-interacting proteins function to modulate STAT3-mediated signaling at various steps and mediate the crosstalk of STAT3 with other cellular signaling pathways. This article reviews the roles of novel STAT3 binding partners such as DAXX, zipper-interacting protein kinase, Krüppel-associated box-associated protein 1, Y14, PDZ and LIM domain 2 and signal transducing adaptor protein-2, in the regulation of STAT3-mediated signaling.