Open AccessRoles and mechanisms of the CD38/cyclic adenosine diphosphate ribose/Ca2+signaling pathway
Author(s) -
Wenjie Wei
Publication year - 2014
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v5.i1.58
Subject(s) - cyclic adp ribose , cd38 , second messenger system , cyclase , microbiology and biotechnology , cyclic adenosine monophosphate , signal transduction , intracellular , extracellular , cell signaling , nicotinamide adenine dinucleotide , nad+ kinase , biochemistry , chemistry , calcium signaling , biology , enzyme , receptor , stem cell , cd34
Mobilization of intracellular Ca(2+) stores is involved in many diverse cell functions, including: cell proliferation; differentiation; fertilization; muscle contraction; secretion of neurotransmitters, hormones and enzymes; and lymphocyte activation and proliferation. Cyclic adenosine diphosphate ribose (cADPR) is an endogenous Ca(2+) mobilizing nucleotide present in many cell types and species, from plants to animals. cADPR is formed by ADP-ribosyl cyclases from nicotinamide adenine dinucleotide. The main ADP-ribosyl cyclase in mammals is CD38, a multi-functional enzyme and a type II membrane protein. It has been shown that many extracellular stimuli can induce cADPR production that leads to calcium release or influx, establishing cADPR as a second messenger. cADPR has been linked to a wide variety of cellular processes, but the molecular mechanisms regarding cADPR signaling remain elusive. The aim of this review is to summarize the CD38/cADPR/Ca(2+) signaling pathway, focusing on the recent advances involving the mechanism and physiological functions of cADPR-mediated Ca(2+) mobilization.