Open AccessIkaros in hematopoiesis and leukemia
Author(s) -
Sinisa Dovat
Publication year - 2011
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v2.i6.105
Subject(s) - haematopoiesis , regulator , medicine , myeloid leukemia , master regulator , chromatin , function (biology) , leukemia , myeloid , chromatin remodeling , immunology , biology , cancer research , gene , microbiology and biotechnology , stem cell , genetics , transcription factor
Ikaros is a gene whose activity is essential for normal hematopoiesis. Ikaros acts as a master regulator of lymphoid and myeloid development as well as a tumor suppressor. In cells, Ikaros regulates gene expression via chromatin remodeling. During the past 15 years tremendous advances have been made in understanding the role of Ikaros in hematopoiesis and leukemogenesis. In this Topic Highlights series of reviews, several groups of international experts in this field summarize the experimental data that is shaping the emerging picture of Ikaros function at the biochemical and cellular levels. The articles provide detailed analyses of recent scientific advancements and present models that will serve as a basis for future studies aimed at developing a better understanding of normal hematopoiesis and hematological malignancies and at accelerating the application of this knowledge in clinical practice.