Open AccessRegulation of cancer cell migration and invasion by sphingosine-1-phosphate
Author(s) -
James R. Van Brocklyn
Publication year - 2010
Publication title -
world journal of biological chemistry
Language(s) - English
Resource type - Journals
ISSN - 1949-8454
DOI - 10.4331/wjbc.v1.i10.307
Subject(s) - sphingosine 1 phosphate , crosstalk , metastasis , angiogenesis , sphingosine , cancer cell , cell growth , cell migration , sphingolipid , microbiology and biotechnology , cell , cancer , cancer research , sphingosine 1 phosphate receptor , receptor , medicine , biology , biochemistry , physics , optics
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that has been implicated in regulation of a number of cancer cell malignant behaviors, including cell proliferation, survival, chemotherapeutic resistance and angiogenesis. However, the effects of S1P on cancer cell migration, invasion and metastasis, are perhaps its most complex, due to the fact that, depending upon the S1P receptors that mediate its responses and the crosstalk with other signaling pathways, S1P can either positively or negatively regulate invasion. This review summarizes the effects of S1P on cancer cell invasion and the mechanisms by which it affects this important aspect of cancer cell behavior.