Open AccessRelationship between coronary artery ectasia, cocaine abuse and acute coronary syndromes
Author(s) -
Gregory Dendramis,
Claudia Paleologo,
Davide Piraino,
Pasquale Assennato
Publication year - 2016
Publication title -
world journal of cardiology
Language(s) - English
Resource type - Journals
ISSN - 1949-8462
DOI - 10.4330/wjc.v8.i5.351
Subject(s) - medicine , coronary artery ectasia , acute coronary syndrome , ectasia , cardiology , cocaine abuse , chest pain , unstable angina , angina , artery , stenosis , coronary angiography , myocardial infarction , psychiatry
Coronary artery ectasia (CAE) often represents a coronary angiography finding casually detected or following the occurrence of an acute coronary syndrome. The pathogenetic role of cocaine abuse in the genesis of CAE is still little known and very few data are available in literature. We describe a case of a 31-year-old male cocaine user admitted to our department for typical acute chest pain. Coronary angiography showed diffuse coronary ectasia with slow flows and without hemodynamically significant stenosis. An increasing of matrix metalloproteinases values and a reduction of their tissue inhibitors was showed both during hospitalization and at one month after discharge. This case report emphasizes the close relationship between cocaine abuse, CAE and acute coronary syndromes in patients without hemodynamically significant coronary stenosis. As reported by Satran et al, cocaine abuse should be considered an important risk factor for CAE and these patients appear to be at increased risk of angina and acute myocardial infarct. Further studies that can strengthen this hypothesis would be useful to deepen and better analyze this interesting association.