Open AccessInteraction of hyperlipidemia and reactive oxygen species: Insights from the lipid-raft platform
Author(s) -
Eisuke Amiya
Publication year - 2016
Publication title -
world journal of cardiology
Language(s) - English
Resource type - Journals
ISSN - 1949-8462
DOI - 10.4330/wjc.v8.i12.689
Subject(s) - lipid raft , reactive oxygen species , nadph oxidase , microbiology and biotechnology , oxidative stress , hyperlipidemia , lipid metabolism , raft , lipid droplet , chemistry , biochemistry , signal transduction , biology , endocrinology , organic chemistry , copolymer , diabetes mellitus , polymer
Reactive oxygen species (ROS) and oxidative stress are closely associated with the development of atherosclerosis, and the most important regulator of ROS production in endothelial cells is NADPH oxidase. Activation of NADPH oxidase requires the assembly of multiple subunits into lipid rafts, which include specific lipid components, including free cholesterol and specific proteins. Disorders of lipid metabolism such as hyperlipidemia affect the cellular lipid components included in rafts, resulting in modification of cellular reactions that produce ROS. In the similar manner, several pathways associating ROS production are affected by the presence of lipid disorder through raft compartments. In this manuscript, we review the pathophysiological implications of hyperlipidemia and lipid rafts in the production of ROS.